Professor Catherine Murphy
Professor Murphy received two B.S. degrees, one in chemistry and one in biochemistry, from the University of Illinois in 1986. She received her Ph.D. from the University of Wisconsin in 1990. From 1990-1993, she was first an NSF and then an NIH postdoctoral fellow at the California Institute of Technology. From 1993-2009 Professor Murphy was a faculty member in the Department of Chemistry and Biochemistry at the University of South Carolina. In August 2009 she joined the faculty of the Department of Chemistry at the University of Illinois.
Our research is at the interface of materials chemistry, inorganic chemistry, biophysical chemistry and nanotechnology. Our primary goal is to develop inorganic nanomaterials for biological and energy-related applications, and understand the chemical interactions of these nanomaterials with their surroundings. A diverse range of projects are currently pursued in the group:
Inorganic Nanoparticle Fabrication and Functionalization.
"Finely-divided metals" such as gold, silver and copper have been known since Roman times for their brilliant colors. These brilliant colors arise fundamentally from the interaction of light with the conduction band electrons in these nanoscale metal particles, producing what is known as a plasmon resonance at particular optical frequencies. Nanorods, compared to nanospheres, have multiple plasmon bands whose position and intensity are intimately connected to the size, shape, degree of aggregation, and local dielectric environment of the nanorods. The absorption and scattering of light by gold and silver nanorods can be tuned throughout the visible and near-infrared portions of the electromagnetic spectrum. We have developed a set of synthetic approaches to fabricate gold and silver nanorods of controlled size and shape in high yields. Molecules can be placed on the nanorod surface using covalent attachment chemistries or polyelectrolyte layer-by-layer adsorption to position them at desired distances, and possibly orientations, from the nanoscale metal surface. On-particle reactions are being explored to improve the compatibility and ease of processing of these materials.
Cellular Imaging, Chemical Sensing, and Photothermal Therapy Using Gold Nanorods.
The strong plasmon bands of noble metal nanoparticles make them ideal for biological sensing and imaging applications. We have used the elastic light scattering properties of gold nanorods as "nano strain gauges" to measure the deformation of soft matrices by living cells. The inelastic light scattering (Raman) properties of gold nanorods can be used to interrogate the local chemical environment of the nanorods. Irradiation into nanorod plasmon bands causes large temperature jumps in the local environment, which we have exploited as a way to kill multidrug-resistant bacteria (once the nanorods are surface-modified to recognize the bacteria).
Environmental Implications of Nanoparticles.
How are nanoparticles distributed and modified in complex biological systems? Can nanoparticles sequester or deliver small molecules across interfaces? How do these processes depend, if at all, on nanoparticle size, shape, aggregation state, and surface chemistry? These are questions that we seek to address using a battery of analytical, physical, and biochemical techniques.
2017 Fellow of the Materials Research Society
2015 Elected Member, U.S. National Academy of Sciences
2015 TREE Award, Research Corporation for Science Advancement
2014 Fellow of the Royal Society of Chemistry
2013 Carol Tyler Award, International Precious Metals Institute
2011 Fellow of the American Chemical Society
2011 Inorganic Nanoscience Award, Division of Inorganic Chemistry, American Chemical Society
Chang, H-H, and C. J. Murphy Mini Gold Nanorods with Tunable Plasmonic Peaks beyond 1000 nm Chem Mater 30 2018, p. 1427-1435.
Metch, J. W, N. D. Burrows, C. J. Murphy, P. J. Vikesland, and A. Pruden Metagenomic Analysis of Microbial Communities Yields Insight into Impacts of Nanoparticle Design Nature Nanotechnology 13 2018, p. 253-259.
Buchman, J T, A. Rahnamoun, K. M. Landy, X. Zhang, A. M. Vartanian, L. M. Jacob, C. J. Murphy, R. Hernandez, and C. L. Haynes Using an environmentally-relevant panel of Gram-negative bacteria to assess the toxicity of poly(allylamine) hydrochloride-wrapped gold nanoparticles Environ. Sci.:Nano 5 2018, p. 279-288.
Lin, W, and C. J. Murphy A Demonstration of LeChatelier’s Principle on the Nanoscale, ACS Central Science 3 2017, p. 1096-1102.
Dennison, J. M, J. Zupancic, W. Lin, J. Dwyer, and C. J. Murphy Protein Adsorption to Charged Gold Nanospheres as a Function of Protein Deformability Langmuir 33 2017, p. 7751-7761.
Hinman, J. G, J. M. Eller, W. Lin, J. Li, and C. J. Murphy Oxidation State of Capping Agent Affects Spatial Reactivity on Gold Nanorods J. Am. Chem. Soc. 139 2017, p. 9851-9854.
Melby, E. S, S. E. Lohse, J. E. Park, A. M. Vartanian, B. A. Putans, H. B. Abbott, R. J. Hamers, C. J. Murphy, and J. A. Pedersen Cascading Effects of Nanoparticle Coatings: Surface Functionalization Dictates the Assemblage of Complexed Proteins and Subsequent Interaction with Model Cell Membranes ACS Nano 11 2017, p. 5489-5499.
McCoy, A. B., Shea, J. E., Murphy, C. J., & Schatz, G. C. (2019). Editorial for January 2019 for JPC A/B/C. Journal of Physical Chemistry C, 123(1), 1-9. https://doi.org/10.1021/acs.jpcc.8b11563
McCoy, A. B., Shea, J. E., Murphy, C. J., & Schatz, G. C. (2019). Editorial for January 2019 for JPC A/B/C. Journal of Physical Chemistry A, 123(1), 1-9. https://doi.org/10.1021/acs.jpca.8b11565
McCoy, A. B., Shea, J. E., Murphy, C. J., & Schatz, G. C. (2019). Editorial for January 2019 for JPC A/B/C. Journal of Physical Chemistry B, 123(1), 1-9. https://doi.org/10.1021/acs.jpcb.8b11564
Hofmann, D. M., Fairbrother, D. H., Hamers, R. J., & Murphy, C. J. (2019). Two-Phase Synthesis of Gold-Copper Bimetallic Nanoparticles of Tunable Composition: Toward Optimized Catalytic CO2 Reduction. ACS Applied Nano Materials, 2(6), 3989-3998.https://doi.org/10.1021/acsanm.9b00904
Tollefson, E. J., Allen, C. R., Chong, G., Zhang, X., Rozanov, N. D., Bautista, A., ... Hernandez, R. (2019). Preferential binding of cytochrome c to anionic ligand-coated gold nanoparticles: A complementary computational and experimental approach. ACS Nano, 13(6), 6856-6866. https://doi.org/10.1021/acsnano.9b01622